The Mayo Clinic offers this overview of tumor necrosis factor-alpha (TNF-alpha) inhibitor medications used to treat inflammatory conditions like rheumatoid arthritis and Crohn's disease. Mayo Clinic staff members explain the conditions that specific drugs like Humira, Enbrel, and Remicade are designed to treat as well as how the drugs work to relieve symptoms. They also give information on weighing the risks and benefits of taking these medications.